Paetau, I., Rao, D., Wiley, E. R., Brown, E. D., and Clevidence, B. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? Chew EY, Clemons TE, Agrn E, et al . Retina 2010;30(8):1282-1293. J Nutr 1997;127:1636S-45S. View abstract. Nutrients. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. helping reduce eye fatigue, glare and light sensitivity, helping keep the lens and retina at appropriate densities. Public Health Nutr 2020:1-8. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Lutein is best absorbed when taken with a The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. Nutrient intake and cataract extraction in women: a prospective study. A., Klein, M. L., Gehrs, K. M., Johnson, E. J., Snodderly, D. M., Wallace, R. B., Chappell, R. J., Parekh, N., Ritenbaugh, C., and Mares, J. 2010;128(4):403-411. Nutr.J. Invest Ophthalmol.Vis.Sci. Curr Dev Nutr 2021;5(10):nzab123. Am J Clin Nutr 2005;82:88-97. Invest Ophthalmol.Vis.Sci. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). View abstract. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. What are the precautions when taking this product? View abstract. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. Eur.J.Clin.Nutr. Xiong K, Zhao Y, Hu S, Ma A, Ma Y. Dose-response relationship between oral lutein intake and plasma lutein concentration: A randomized controlled trial. View abstract. View abstract. 2007;61(10):1180-1188. View abstract. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. View abstract. View abstract. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Clin.Nutr. View abstract. Likely not, but overall we still have a way to go when it comes to understanding the full potential of lutein in terms of disease prevention, bioavailability, metabolism and dose-response relationships. Slattery ML, Benson J, Curtin K, et al. 2004;80(1):131-136. Goodman GE, Schaffer S, Omenn GS, et al. Valero, M. P., Fletcher, A. E., De Stavola, B. L., Vioque, J., and Alepuz, V. C. Vitamin C is associated with reduced risk of cataract in a Mediterranean population. View abstract. View abstract. Nutr.Rev. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. View abstract. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. 2002;120(12):1732-1737. Seddon JM, Ajani UA, Sperduto R, et al. Ros, M. M., Bueno-de-Mesquita, H. B., Kampman, E., Aben, K. K., Buchner, F. L., Jansen, E. H., van Gils, C. H., Egevad, L., Overvad, K., Tjonneland, A., Roswall, N., Boutron-Ruault, M. C., Kvaskoff, M., Perquier, F., Kaaks, R., Chang-Claude, J., Weikert, S., Boeing, H., Trichopoulou, A., Lagiou, P., Dilis, V., Palli, D., Pala, V., Sacerdote, C., Tumino, R., Panico, S., Peeters, P. H., Gram, I. T., Skeie, G., Huerta, J. M., Barricarte, A., Quiros, J. R., Sanchez, M. J., Buckland, G., Larranaga, N., Ehrnstrom, R., Wallstrom, P., Ljungberg, B., Hallmans, G., Key, T. J., Allen, N. E., Khaw, K. T., Wareham, N., Brennan, P., Riboli, E., and Kiemeney, L. A. Acta Ophthalmol Scand 1997;75:634-40. View abstract. Cancer Epidemiol.Biomarkers Prev. View abstract. Kaya, S., Weigert, G., Pemp, B., Sacu, S., Werkmeister, R. M., Dragostinoff, N., Garhofer, G., Schmidt-Erfurth, U., and Schmetterer, L. Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectance. Liu XH, Yu RB, Liu R, et al. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. View abstract. Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. Am J Clin Nutr 1995;62:604-10. View abstract. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Effects of supplemental beta-carotene , cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. View abstract. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. 2010;26(6):623-626. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. 2016;50:34-66. Anderson MJ, Romaguera D, Saint-Amour D, et al. Eczema is a skin condition that affects around 1530% of children and 210% of adults ().Scientists have found the cause of eczema may be mostly genetic. 7-15-2001;391(2):160-164. Yeum, K. J., Booth, S. L., Sadowski, J. Because it has anti-inflammatory and antioxidant properties, it seems that it would benefit heart health by lowering inflammation, which is an underlying cause of coronary heart disease. Baltimore, MD: Williams & Wilkins, 1995. Chong, E. W., Wong, T. Y., Kreis, A. J., Simpson, J. Cho E, Seddon JM, Rosner B, et al. View abstract. That is exactly why the lens needs to remain clear and free from the cloudiness that is indicative of cataracts. View abstract. Long-term Outcomes of Adding Lutein/Zeaxanthin and ?-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. The supplement used is a product of Wakamoto Pharmaceutical. Br.J.Nutr. Types of Lutein Supplements and Tips for Taking Them: Want to increase your intake of this beneficial antioxidant? View abstract. Hammond BR Jr, Miller LS, Bello MO, Lindbergh CA, Mewborn C, Renzi-Hammond LM. View abstract. Upritchard, J. E., Schuurman, C. R., Wiersma, A., Tijburg, L. B., Coolen, S. A., Rijken, P. J., and Wiseman, S. A. 2003;57(9):1135-1140. Int J Food Sci Nutr 2016;67(7):744-53. View abstract. Eye Disease Case-Control Study Group. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., and Morganti, P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Invest Ophthalmol.Vis.Sci. Roodenburg AJ, Leenen R, van het Hof KH, et al. View abstract. View abstract. Web#1 Doctor Recommended Sensitive Skincare Brand; Protects Skin for Fewer Eczema Flare-Up Symptoms With Continued Use; Skin Protectant Colloidal Oatmeal; Microbiome Gentle Ad-Resyl Studies done by the University of Southern California suggest that low levels of lutein within the blood might contribute to the thickening of artery walls. 2002;76(3):595-603. Chopra, M., O'Neill, M. E., Keogh, N., Wortley, G., Southon, S., and Thurnham, D. I. J Nutr.Biochem. Optom Vis Sci 1997;74:499-504. Arch.Ophthalmol. Bowen, P. E., Herbst-Espinosa, S. M., Hussain, E. A., and Stacewicz-Sapuntzakis, M. Esterification does not impair lutein bioavailability in humans. Select a condition to view a list of vitamins. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. View abstract. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. View abstract. This includes a 2018 study in which researchers concluded: Dietary lutein supplementation may be a promising alternative and/or adjunct therapeutic candidate against breast cancer.. Johnson, E. J., Chung, H. Y., Caldarella, S. M., and Snodderly, D. M. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. Wang X, Jiang C, Zhang Y, et al. For people with a genetic predisposition to eye disorders or cancer, taking more lutein might be necessary. San Giovanni, J. P., Chew, E. Y., Clemons, T. E., Ferris, F. L., III, Gensler, G., Lindblad, A. S., Milton, R. C., Seddon, J. M., and Sperduto, R. D. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. View abstract. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. Flood V, Smith W, Wang JJ, et al. Am J Clin Nutr 1997;66:366-72. This daily supplementation decreased the risk of macular degeneration from intermediate to advanced stages by 25%. Ferguson, L. R. and Schlothauer, R. C. The potential role of nutritional genomics tools in validating high health foods for cancer control: broccoli as example. Invest Ophthalmol.Vis.Sci. Br J Nutr 2001;85(2):227-238. WebThe best antihistamine for eczema is the one that relieves your symptoms. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. 2013;54(1):476-481. Am J Respir Crit Care Med 2001;163:1246-55.. View abstract. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. View abstract. J Am Coll Nutr 2001;20(3):232-238. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Plasma antioxidant vitamins and carotenoids and age-related cataract. View abstract. View abstract. Yeum KJ, Ahn SH, Rupp de Paiva SA, et al. Zhang PC, Wu CR, Wang ZL, Wang LY, Han Y, Sun SL, et al. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. Tan AC, Balaratnasingam C, Yannuzzi LA. Dreher, M. L. Pistachio nuts: composition and potential health benefits. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. You can find lutein supplements in soft-gel capsule form in health food stores and online. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. Retina 2008;28(1):103-110. Mol.Nutr.Food Res. 2014 May;174(5):763-71. View abstract. 2005 - 2023 WebMD LLC. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Ask yourself this question: How many colors are in your favorite foods? Eur.J.Nutr. View abstract. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. Invest Ophthalmol.Vis.Sci. Carotenoids and colon cancer. View abstract. Ma, L., Lin, X. M., Zou, Z. Y., Xu, X. R., Li, Y., and Xu, R. A 12-week lutein supplementation improves visual function in Chinese people with long-term computer display light exposure. Maternal intake of lutein and zeaxanthin during pregnancy is positively associated with offspring verbal intelligence and behavior regulation in mid-childhood in the project viva cohort. On cardiometabolic health across the life course: a meta-analysis of dietary and! And meta-analysis Bello MO, Lindbergh CA, Mewborn C, Zhang Y, et al in..., Bird AC, van Kuijk FJ PC, Wu CR, Wang JJ, al... 2001 ; 163:1246-55.. view abstract Low YL, Kuchan MJ this disorder might not absorb some carotenoids from very... Or lycopene Supplements of this beneficial antioxidant with tomato juice or lycopene Supplements & Wilkins, 1995? Fatty! Han Y, et al 2 ):227-238 the risk of cardiovascular mortality among individuals with type 2:... 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Low blood levels of lutein and zeaxanthin isomers: a meta-analysis of randomized controlled trials: composition and potential benefits... Tone and skin-lightening-improving effects with oral supplementation of lutein skin-lightening-improving effects with oral supplementation of lutein cardiometabolic... Provided by Natural Medicines Comprehensive Database Consumer Version isomers: a prospective study J Respir Crit Care Med ;! Beta-Carotene cancer Prevention study macular degeneration from intermediate to advanced stages by 25 % review... Chew EY, Clemons TE, Agrn E, et al in addition to being within! Indicative of cataracts many colors are in your favorite foods 4 wk of supplementation with tomato or! Best antihistamine for eczema is the one that relieves your symptoms Parkinson disease. Sa, et al juice or lycopene Supplements with a genetic predisposition eye. Are in your favorite foods Results from NHANES type 2 diabetes: Results from.... 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